Lyme disease (also called Borrelia burgdorferi) vaccine is recommended only for dogs in high-risk areas. This includes dogs visiting areas where Lyme disease is prevalent and areas with a high risk of tick exposure.
The killed bacterin version is now out of favor and the subunit vaccine, featuring the OpsA antigen, is recommended if the vaccine is needed. The immunity from this vaccine can be distinguished from a natural exposure. Tick control should be the first line of defense against Lyme disease.